Early diagnosis of acute kidney injury (AKI):
The levels of NGAL in plasma and urine of patients with severe burns remained high and were independently associated with the development of AKI and the mortality within 48h after admission.
Clinical studies of acute rejection after renal transplantation and AKI after disseminated intravascular coagulation have found that blood NGAL is of great value in early diagnosis and prognosis evaluation of disease.
The application of contrast agents such as cardiovascular angiography and coronary intervention (PCI) makes contrast-enhanced kidney disease one of the most important diseases of hospital-acquired renal failure. A large number of studies have found that a large amount of NGAL can be detected in renal tubular cells, urine and plasma of patients after PCI, which may be related to the toxicity of the contrast agent to renal tubules and the mechanism of ischemic injury.
NGAL participates in the pathophysiological processes of various chronic kidney diseases to varying degrees, such as lupus nephritis, IgA nephropathy, glomerulonephritis, polycystic kidney disease, delayed type rejection after renal transplantation, and diabetic nephropathy, etc.