l Routine monitoring of critically ill patients
AKI has a prevalence of more than 50% in the ICU and a mortality rate of 50-80% in patients who are to be dialyzed. NGAL is capable of early diagnosis of AKI complications in critically ill patients.
l Early diagnosis of AKI after organ transplantation
Routine testing after kidney transplantation allows early assessment of the need for dialysis and functional recovery of the transplanted kidney within 1 week after surgery.
l Postoperative monitoring of coronary artery bypass grafting (CABG)
Earlier diagnosis of acute kidney injury in patients undergoing CABG can be achieved by measuring postoperative plasma NGAL concentration at 2 h.
l Early diagnosis of contrast-induced nephropathy (CIN)
² Urinary NGAL of CIN patients showed significant changes 24h after angiography, while levels of other markers such as serum creatinine (SCr) concentration do not change significantly at this time.
² NGAL rises rapidly in response to kidney injury, preceding changes in creatinine by as much as 2 to 3 days.
l Prediction of the risk of progression of chronic kidney disease (CKD)
The risk of CKD progression can increase by 3% and 2% for each 10 ng/mL increase in serum NGAL and urine NGAL concentrations, respectively.